org.simBio.bio.kuratomi_et_al_2003.current.carrier
Class INaCa

java.lang.Object
  org.simBio.core.Component
      org.simBio.core.Parameter
          org.simBio.core.Composite
              org.simBio.core.Reactor
                  org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter
                      org.simBio.bio.kuratomi_et_al_2003.current.carrier.Carrier
                          org.simBio.bio.kuratomi_et_al_2003.current.carrier.INaCa

All Implemented Interfaces:

Node

public class INaCa
extends Carrier

Na/Ca exchanger. inactivation gate is incorporated at 2004/07/26.

Author:

modified by B.J. Kim, Nobuaki Sarai

See Also:

Kuratomi S, Matsuoka S, Sarai N, Powell T, Noma A. Involvement of Ca²⁺ buffering and Na⁺/Ca²⁺ exchange in the positive staircase of contraction in guinea-pig ventricular myocytes. Pflugers Arch 446: 347-355, 2003.
Eqs (2)-(9) in Table 7 in Matsuoka et al, 2003

Field Summary

Node	Cai concentration of intracellular Calcium[mM]
Node	Cao concentration of intracellular Calcium[mM]
double	F Faraday constant default value is 96.4867[C/mmol]
Node	inActivation inactivation gate
double	KmCai dissociation constant for intracellular Calcium [mM]
double	KmCao dissociation constant for intracellular Calcium [mM]
double	KmNai dissociation constant for intracellular Sodium[mM]
double	KmNao dissociation constant for extracellular Sodium[mM]
Node	Nai concentration of intracellular Sodium [mM]
Node	Nao concentration of intracellular Sodium [mM]
double	nHNa experimental index for Hill constant about Sodium
double	partition distribution constant
double	R gas constant default value is 8.3143[C*mV/K/mmol]
Node	T absolute temperature[K]
Node	Vm membrane potential of cell[mV]

Fields inherited from class org.simBio.bio.kuratomi_et_al_2003.current.carrier.Carrier

amplitude, Cm, E1A, E1B, E2A, E2B, gate, inactive, k1, k2, k3, k4, stoichiometryCa, stoichiometryK, stoichiometryNa

Fields inherited from class org.simBio.bio.matsuoka_et_al_2003.current.MembraneTransporter

cCa, CCa, cK, CK, cNa, CNa, current, currentCa, currentK, currentNa, total

Fields inherited from class org.simBio.core.Parameter

value

Constructor Summary

INaCa()

Method Summary

protected void	calculate(double t) calculate total charge movement using reduced 2 state model 2 state gateを用いて電流を計算する
void	prepare() construct null current

Methods inherited from class org.simBio.core.Composite

accept, getLink, getNode, getNodesIterator, getNodesSize

Methods inherited from class org.simBio.core.Parameter

addValue, getValue, getValueString, setInitializer, setValue, setValueString, setValueToField

Methods inherited from class org.simBio.core.Component

addDydt, end, getIndent, getIndentedShortName, getName, getName, getParent, getRoot, getShortName, getUnits, isNamed, isPrefixed, logIndented, quit, setLinks

Methods inherited from class java.lang.Object

clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait

Methods inherited from interface org.simBio.core.Node

addDydt, addValue, getValue, setValue

Field Detail

Nai

public Node Nai

concentration of intracellular Sodium [mM]

Nao

public Node Nao

concentration of intracellular Sodium [mM]

Cai

public Node Cai

concentration of intracellular Calcium[mM]

Cao

public Node Cao

concentration of intracellular Calcium[mM]

Vm

public Node Vm

membrane potential of cell[mV]

T

public Node T

absolute temperature[K]

R

public double R

gas constant default value is 8.3143[C*mV/K/mmol]

F

public double F

Faraday constant default value is 96.4867[C/mmol]

KmNao

public double KmNao

dissociation constant for extracellular Sodium[mM]

KmNai

public double KmNai

dissociation constant for intracellular Sodium[mM]

KmCao

public double KmCao

dissociation constant for intracellular Calcium [mM]

KmCai

public double KmCai

dissociation constant for intracellular Calcium [mM]

nHNa

public double nHNa

experimental index for Hill constant about Sodium

partition

public double partition

distribution constant

inActivation

public Node inActivation

inactivation gate

Constructor Detail

INaCa

public INaCa()

Method Detail

calculate

protected void calculate(double t)

Description copied from class: Carrier

calculate total charge movement using reduced 2 state model
2 state gateを用いて電流を計算する

Overrides:

calculate in class Carrier

Parameters:

t - time

prepare

public void prepare()

Description copied from class: MembraneTransporter

construct null current

Overrides:

prepare in class MembraneTransporter

See Also:

Component.prepare()